doi: 10.1016/bs.apha.2019.08.002 18
Pregnancy If you are pregnant or planning to conceive, it is advisable to discuss this with your doctor before taking GLUTONE INJECTION 1
In certain embodiments, any controlled-release otic formulation described herein increases the exposure time of an active agent and decreases the C max in otic fluids (e.g., endolymph and/or perilymph) by about 40%, about 30%, about 20%, or about 10%, compared to a formulation that is not a controlled-release otic formulation
Its mechanism is purely metabolic: it directly targets lipid metabolism via inhibition of NNMT and restoration of cellular NAD+
Enzymatic treatment included 40U DNase-I, 1000 g/ml Amylase, 500 g/ml Proteinase K and a combination of 40U DNase-I + 4 g/mL amikacin or 40U DNase-I + 30 mM GSH